Platelet lipid composition and platelet aggregation in human liver disease

Platelet lipid composition and platelet aggregation

Abnormal plasma lipoproteins in patients with liver disease are associated with an increase in erythrocyte cholesterol concentration and a raised erythrocyte cholesteroVphosphoEpid molar ratio. We hypothesized that their platelets would also have an increased cholesteroVphospholipid ratio and that this might affect aggregation in vitro. Platelet aggregation by adrenaline and ADP was measured in...

Platelet function and platelet lipid composition in the dyslipoproteinemias.

Blood platelets from eight patients with hyperbetalipoproteinemia (type II) were more reactive to aggregating agents in vitro than those of 13 type IV patients or 12 normal subjects. Platelets of two patients with abeta-lipoproteinemia were also slightly hyperreactive in comparison with normal platelets. However, in one patient with Tangier disease the platelets were distinctly hyporeactive to ...

Reduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the platelets.

AIMS High plasma cholesterol concentration and increased platelet activity are two major risk factors for atherosclerosis. Lovastatin, the lipophilic drug was shown to inhibit platelet aggregation whereas pravastatin, the hydrophilic drug had no such effect. Analysis of the effect of fluvastatin which is both a lipophilic and hydrophilic drug, on platelet aggregation was the goal of the present...

PLATELET AGGREGATION IN CORONARY DISEASE/Mehta

5. Faria JL de: Uber die Atiologie und die formale Pathogenese der Medionecrosis aortae idiopathica. Beitr Pathol 117: 202, 1957 6. Geiringer E: Intimal vascularization and athermatosis. J Pathol 6: 201, 1951 7. Wolinsky H, Glagov S: Comparison of abdominal and thoracic aortic medial structure in mammals. Circ Res 25: 677, 1969 8. Anagnostopoulos CE: Acute aortic dissections. Baltimore, Univers...

Platelet aggregation, platelet serotonin and pancreatitis.